The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential …

H Zalpoor, A Akbari, A Samei… - Cellular & Molecular …, 2022 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …

SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment

C Shang, Z Liu, Y Zhu, J Lu, C Ge, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …

Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome

I Sulaiman, M Chung, L Angel, JCJ Tsay, BG Wu… - Nature …, 2021 - nature.com
Respiratory failure is associated with increased mortality in COVID-19 patients. There are no
validated lower airway biomarkers to predict clinical outcome. We investigated whether …

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

TJ Costa, SR Potje, TFC Fraga-Silva… - Vascular …, 2022 - Elsevier
Background and purpose Mitochondria play a central role in the host response to viral
infection and immunity, being key to antiviral signaling and exacerbating inflammatory …

Differential effects of SARS-CoV-2 variants on central nervous system cells and blood–brain barrier functions

A Proust, CJ Queval, R Harvey, L Adams… - Journal of …, 2023 - Springer
Background Although mainly causing a respiratory syndrome, numerous neurological
symptoms have been identified following of SARS-CoV-2 infection. However, how the virus …

Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems

AVW Nunn, GW Guy, W Brysch, JD Bell - Biomedicines, 2022 - mdpi.com
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …

SARS-CoV-2: a master of immune evasion

A Rubio-Casillas, EM Redwan, VN Uversky - Biomedicines, 2022 - mdpi.com
Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

Role of mitochondria in viral infections

S Elesela, NW Lukacs - Life, 2021 - mdpi.com
Viral diseases account for an increasing proportion of deaths worldwide. Viruses maneuver
host cell machinery in an attempt to subvert the intracellular environment favorable for their …

Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications

AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …