Tight junctions (TJ) are multi-protein complexes located at the apicalmost tip of the lateral
membrane in polarised epithelial and endothelial cells. Their principal function is in …

Tight junctions (TJs) play an important role in maintaining cell polarity and regulating cell
permeability. In recent years, many studies have shown that TJ proteins, especially claudin …

Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT,
and mesenchymal states, each of which is associated with cancer progression, invasive …

Background Colorectal cancer (CRC) is a common malignant tumour of the digestive tract
that is characterized by high patient morbidity and mortality rates. Claudin-7 (Cldn7), a tight …

Abstract Background Claudin-4 (CLDN4), a tight junction protein, is overexpressed in
several types of cancer, and is considered a biomarker for cancer-targeted treatment …

Tight junction complexes are involved in the establishment and maintenance of cell polarity
and the regulation of signalling pathways, controlling biological processes such as cell …

In epithelial cells claudin7 (cld7) is a major component of tight junctions, but is also
recovered from glycolipid-enriched membrane microdomains (GEM). In tumor cells, too, cld7 …

Objective: This study evaluated differences in Claudin-1 expression between follicular
adenoma (FA), follicular thyroid carcinoma (FTC), follicular variant papillary thyroid …

Hepatobiliary and pancreatic diseases are becoming increasingly common worldwide and
associated cancers are prone to recurrence and metastasis. For a more accurate treatment …

Background/objectives Pancreatic cancer consists of various subpopulations of cells, some
of which have aggressive proliferative properties. The molecules responsible for the …