Hydrogels are a class of polymer materials with three-dimensional networks structure, which
can absorb a large number of water and biological fluids. Natural polysaccharides are ideal …

Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

In previous years, three‑dimensional (3D) cell culture technology has become a focus of
research in tumor cell biology, using a variety of methods and materials to mimic the in vivo …

Highlights•Comprehensive review of recent advances in 3D bioprinting techniques for tissue
engineering.•3D bioprinting provides complex 3D biomimetic architectures for 3D cell …

Three-dimensional multicellular spheroids (MCSs) have a complex architectural structure,
dynamic cell–cell/cell–matrix interactions and bio-mimicking in vivo microenvironment. As a …

Electrospinning provides an enabling nanotechnology platform for generating a rich variety
of novel structured materials in many biomedical applications including drug delivery …