ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …

Natural peptides are an important class of chemical mediators, essential for most vital
processes. What limits the potential of the use of peptides as drugs is their low bioavailability …

Abstract A new series of 1, 4, 5-trisubstituted triazole-bearing benzenesulphonamide moiety,
COX-2 pharmacophore, was designed and synthesized. The synthetic pathway for …

A series of benzothiazole and benzoxazole linked 1, 4-disubstituted 1, 2, 3-triazoles was
synthesized through copper (I) catalyzed azide-alkyne cycloaddition reaction. FTIR, 1 H, 13 …

This critical review highlights the advances in developing new molecules for treating pain
syndrome, an important issue for human health. Acetaminophen (APAP, known as …

Bioisosterism is strategically used in drug design to enhance the pharmacokinetic and
pharmacodynamic properties of therapeutic molecules. The average electron density (AED) …

We hereby describe an efficient method for the preparation of a series of new 1-substituted
1, 2, 3-triazole-based acetaminophen derivatives through a clean, good-yielding, simple …

Safe and effective pain management is a critical healthcare and societal need. The potential
for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal …

Cytochrome P450 3A4, the most abundant form of isoenzyme, in combination with several
other isoforms, metabolizes lignocaine into mono-ethylglycine xylidide (MEGX) and …

A series of twenty seven ether linked 1, 4-disubstituted 1, 2, 3-triazoles was assessed for in
vitro antimalarial activity against Plasmodium falciparum, while antibacterial activity against …