Mathematical biology models of Parkinson's disease

S Bakshi, V Chelliah, C Chen… - CPT: pharmacometrics …, 2019 - Wiley Online Library
Parkinsons disease (PD) is a progressive neurodegenerative disease with substantial and
growing socio‐economic burden. In this multifactorial disease, aging, environmental, and …

Brain energetics, mitochondria, and traumatic brain injury

H Benaroya - Reviews in the Neurosciences, 2020 - degruyter.com
We review current thinking about, and draw connections between, brain energetics and
metabolism, and between mitochondria and traumatic brain injury. Energy is fundamental to …

A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen

D Calvetti, GC Rangel, LG Giorda… - Journal of theoretical …, 2018 - Elsevier
The human brain is a small organ which uses a disproportionate amount of the total
metabolic energy production in the body. While it is well understood that the most significant …

Mathematical models for information classification and recognition of multi-target optical remote sensing images

H Zhang, J Han - Open Physics, 2020 - degruyter.com
Traditionally, three-dimensional model is used to classify and recognize multi-target optical
remote sensing image information, which can only identify a specific class of targets, and …

Brain energy metabolism

D Calvetti, E Somersalo - Encyclopedia of computational neuroscience, 2022 - Springer
The balanced state of neurons is characterized by a high value of the total membrane
conductance caused by synaptic inputs. It is the state of cortical neurons in vivo in awake …

MITODYN: An open source software for quantitative modeling of mitochondrial and cellular energy metabolic flux dynamics in health and disease

VA Selivanov, OA Zagubnaya, C Foguet… - … Systems Biology in …, 2022 - Springer
Mitochondrial respiratory chain (RC) transforms the reductive power of NADH or FADH2
oxidation into a proton gradient between the matrix and cytosolic sides of the inner …

Multiscale flux-based modeling of biofilm communities

T Zhang, A Parker, RP Carlson, PS Stewart… - Multiscale Modeling & …, 2020 - SIAM
Models of microbial community dynamics generally rely on a subscale description for
microbial metabolisms. In systems such as distributed multispecies communities like …

Mathematical modeling of lactate metabolism in the brain

M Soltanzadeh - 2021 - spectrum.library.concordia.ca
It is well established that the primary substrate for brain energy metabolism is glucose, but
accumulating evidence suggests that lactate can also be considered as an energy substrate …

Dynamical aspects of pharmacokinetic/pharmacodynamic & quantitative systems pharmacology models

I Loisios-Konstantinidis, PD Mavroudis… - … and Systems Approach …, 2020 - Springer
Physiological systems are inherently dynamic and complex. The erratic nature and the
irregular behavior of these systems has been the subject of several studies in the field of …

Computational predictive modeling of integrated cerebral metabolism, electrophysiology and hemodynamics

G Capo - 2019 - bird.bcamath.org
Understanding the energetic requirement of brain cells during resting state and during high
neuronal activity is a very active research area where mathematical models have …