The remarkable clinical activity of chimeric antigen receptor (CAR) therapies in B cell and
plasma cell malignancies has validated the use of this therapeutic class for liquid cancers …

Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable
hematological malignancy that affects the myeloid cell progenies and challenges patients of …

Background Cytidine deamination that is guided by clustered regularly interspaced short
palindromic repeats (CRISPR) can mediate a highly precise conversion of one nucleotide …

Chimeric antigen receptor (CAR)-T cell therapy against T cell malignancies faces major
challenges including fratricide between CAR-T cells and product contamination from the …

Derivation of CD7-targeted chimeric antigen receptor (7CAR) T cells often requires genetic
manipulations to ablate the CD7 gene or block CD7 cell surface expression. Our novel …

PURPOSE Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (r/r T-
ALL) have few options and poor prognosis. The aim was to assess donor-derived anti-CD7 …

Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological
malignancies. Macrophages have also gained attention as an immunotherapy owing to their …

Patient-derived T cells genetically reprogrammed to express CD19-specific chimeric antigen
receptors (CARs) have shown remarkable clinical responses and are commercially …

Background Relationships between microbiota composition and clinical outcomes after
allogeneic hematopoietic-cell transplantation have been described in single-center studies …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …