Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes
T Salvatore, R Galiero, A Caturano, E Vetrano… - Biomolecules, 2022 - mdpi.com
Cardiovascular (CV) disease and heart failure (HF) are the leading cause of mortality in type
2 diabetes (T2DM), a metabolic disease which represents a fast-growing health challenge …
2 diabetes (T2DM), a metabolic disease which represents a fast-growing health challenge …
Chemical metabolite synthesis and profiling: mimicking in vivo biotransformation reaction
Biotransformation was previously viewed as merely the structural characterization of drug
metabolites, and it was performed only when drug candidates entered in clinical …
metabolites, and it was performed only when drug candidates entered in clinical …
Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms
Type 2 diabetes mellitus (T2DM) is highly prevalent and associated with a two-fold
increased mortality, mostly explained by cardiovascular diseases. Trial evidence on older …
increased mortality, mostly explained by cardiovascular diseases. Trial evidence on older …
2023 UPDATE: Luso-Brazilian evidence-based guideline for the management of antidiabetic therapy in type 2 diabetes
MC Bertoluci, WS Silva Júnior, F Valente… - Diabetology & Metabolic …, 2023 - Springer
Background The management of antidiabetic therapy in people with type 2 diabetes (T2D)
has evolved beyond glycemic control. In this context, Brazil and Portugal defined a joint …
has evolved beyond glycemic control. In this context, Brazil and Portugal defined a joint …
[HTML][HTML] Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies
Pioglitazone (PGL) is an effective insulin sensitizer, however, side effects such as
accumulation of subcutaneous fat, edema, and weight gain as well as poor oral …
accumulation of subcutaneous fat, edema, and weight gain as well as poor oral …
Additional effect of luseogliflozin on semaglutide in nonalcoholic steatohepatitis complicated by type 2 diabetes mellitus: an open-label, randomized, parallel-group …
T Miyake, O Yoshida, B Matsuura, S Furukawa… - Diabetes Therapy, 2022 - Springer
Introduction Untreated nonalcoholic fatty liver may progress to nonalcoholic steatohepatitis
(NASH) and cirrhosis and induce hepatocellular carcinoma and liver failure. Type 2 diabetes …
(NASH) and cirrhosis and induce hepatocellular carcinoma and liver failure. Type 2 diabetes …
Beyond antithrombotics: recent advances in pharmacological risk factor management for secondary stroke prevention
Patients with ischaemic stroke represent a diverse group with several cardiovascular risk
factors and comorbidities, which classify them as patients at very high risk of stroke …
factors and comorbidities, which classify them as patients at very high risk of stroke …
Pioglitazone, bladder cancer, and the presumption of innocence
GS Papaetis - Current Drug Safety, 2022 - ingentaconnect.com
Background: Thiazolidinediones are potent exogenous agonists of PPAR-γ that augment the
effects of insulin to its cellular targets, mainly at the level of adipose tissue. Pioglitazone, the …
effects of insulin to its cellular targets, mainly at the level of adipose tissue. Pioglitazone, the …
Will lobeglitazone rival pioglitazone? A systematic review and critical appraisal
KK Gangopadhyay, AK Singh - … & Metabolic Syndrome: Clinical Research & …, 2023 - Elsevier
Background and aims Lobeglitazone (LGZ), a newly researched thiazolidinedione (TZD)
thought to have lesser side effects compared with pioglitazone (PGZ), has been recently …
thought to have lesser side effects compared with pioglitazone (PGZ), has been recently …
Contemporary choice of glucose lowering agents in heart failure patients with type 2 diabetes
Introduction There is a bi-directional link between type 2 diabetes mellitus (T2DM) and heart
failure (HF) and their co-existence markedly increases an individual's morbidity and …
failure (HF) and their co-existence markedly increases an individual's morbidity and …