Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FDT) are progressive
neurodegenerative disorders that, in several cases, overlap in clinical presentation, and …

Neuroinflammation is an important pathogenic mechanism in many neurodegenerative
diseases, including those caused by frontotemporal lobar degeneration (FTLD). Postmortem …

Blood-brain barrier (BBB) disruption is an early event in the development of Alzheimer's
disease. It precedes extracellular deposition of amyloid-β in senile plaques and blood …

Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

This paper provides an overview of the role of neuroinflammation in Alzheimer's disease
and other neurodegenerative diseases, highlighting the potential of anti-inflammatory …

Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia
after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease …

TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that
share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43 …

Positron emission tomography (PET) targeting translocator protein 18 kDa (TSPO) can be
used for the noninvasive detection of neuroinflammation. Improved in vivo stability of a …

The behavioral variant of frontotemporal dementia (bvFTD) has a devastating effect on
multiple domains of daily living. The purpose of this PRISMA-compliant systematic review is …