Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

In contrast to ketones and carboxylic esters, amides are classically seen as comparatively
unreactive members of the carbonyl family, owing to their unique structural and electronic …

A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction
employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the …

Medium‐sized N, S‐heterocycles have received tremendous interest due to their biological
activities and potential medical applications. However, asymmetric synthesis of these …

We report herein a straightforward transfer of a free amino group (NH2) from a commercially
available nitrogen source to unfunctionalized, native carbonyls (amides and ketones) …

Precise deuterium incorporation of bioactive molecules is highly desirable in order to
improve ADME properties and monitor pharmacokinetics. Organic electrochemistry offers a …

Developing a membrane-free oxidation reaction, especially using water as the oxygen
source, to generate high-value chemicals with high selectivity for replacing low-value O 2 …

Sulfenyl imidinium salts are a virtually unexplored class of intermediates in organic
chemistry. Herein, we demonstrate how sulfonium rearrangements can be deployed to …

The key carbenoid intermediate of transition-metal-catalyzed furan–yne cyclization in
Hashmi phenol synthesis could be efficiently intercepted with water under the developed …

Bimolecular interactions play crucial roles in lignin pyrolysis. The tautomerization of key
intermediates has a significant impact on the formation of stable products, whereas …