Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive
oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially …

Cysteine occupies a unique place in protein chemistry. The nucleophilic thiol group allows
cysteine to undergo a broad range of redox modifications beyond classical thiol-disulfide …

Reduction-oxidation or “redox” reactions are an integral part of a broad range of cellular
processes such as gene expression, energy metabolism, protein import and folding, and …

Abstract Significance: During the Legume–Rhizobium symbiosis, hydrogen peroxide (H2O2)
and nitric oxide (NO) appear to play an important signaling role in the establishment and the …

Mutations in the type III receptor tyrosine kinase FLT3 are frequent in patients with acute
myeloid leukemia (AML) and are associated with a poor prognosis. AML is characterized by …

Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence,
cysteine often has important functions in a protein, be it as the active site or, in extracellular …

Posttranslational modifications of protein cysteine thiols play a significant role in redox
regulation and the pathogenesis of human diseases. Herein, we report the characterization …

Significance: The post-translational modification of thiol groups stands out as a key strategy
that cells employ for metabolic regulation and adaptation to changing environmental …

RNA structure and function are intimately tied to RNA binding protein recognition and
regulation. Posttranslational modifications are chemical modifications which can control …