The immune response during acute HIV-1 infection: clues for vaccine development

AJ McMichael, P Borrow, GD Tomaras… - Nature Reviews …, 2010 - nature.com
The early immune response to HIV-1 infection is likely to be an important factor in
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …

The detection of acute HIV infection

MS Cohen, CL Gay, MP Busch… - The Journal of infectious …, 2010 - academic.oup.com
Acute human immunodeficiency virus (HIV) infection (AHI) can be defined as the time from
HIV acquisition until seroconversion. Incident HIV infection is less well defined but …

The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling study

KA Powers, AC Ghani, WC Miller, IF Hoffman… - The Lancet, 2011 - thelancet.com
Background HIV transmission risk is higher during acute and early HIV infection than it is
during chronic infection, but the contribution of early infection to the spread of HIV is …

Clinical and public health implications of acute and early HIV detection and treatment: a scoping review

SE Rutstein, J Ananworanich, S Fidler… - African Journal of …, 2017 - journals.lww.com
Methods We conducted a scoping review [28] synthesizing the most recent literature on
clinical and public health implications of widespread AHI detection and treatment. This …

Independent assessment of candidate HIV incidence assays on specimens in the CEPHIA repository

R Kassanjee, CD Pilcher, SM Keating, SN Facente… - Aids, 2014 - journals.lww.com
Objective: Cross-sectional HIV incidence surveillance, using assays that distinguish
'recent'from 'nonrecent'infections, has been hampered by inadequate performance and …

Challenges of HIV diagnosis and management in the context of pre‐exposure prophylaxis (PrEP), post‐exposure prophylaxis (PEP), test and start and acute HIV …

T Elliott, EJ Sanders, M Doherty… - African Journal of …, 2019 - journals.lww.com
Introduction: Knowledge of HIV status relies on accurate HIV testing, and is the first step
towards access to HIV treatment and prevention programmes. Globally, HIV-status …

Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men

M Hoenigl, N Weibel, SR Mehta… - Clinical Infectious …, 2015 - academic.oup.com
Background. Although men who have sex with men (MSM) represent a dominant risk group
for human immunodeficiency virus (HIV), the risk of HIV infection within this population is not …

Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo test

NE Rosenberg, G Kamanga, S Phiri… - Journal of Infectious …, 2012 - academic.oup.com
Abstract (See the editorial commentary by Branson and Stekler, on pages 521–4.)
Background. Most human immunodeficiency virus (HIV) point-of-care tests detect antibodies …

How can we better identify early HIV infections?

NE Rosenberg, CD Pilcher, MP Busch… - Current Opinion in HIV …, 2015 - journals.lww.com
There are important recent advances in detection of EHIs at the individual and population
levels. Applying optimal combinations of tests in diagnostic and HIV incidence algorithms is …

Clinical presentation and diagnosis of primary HIV-1 infection

ES Daar, CD Pilcher, FM Hecht - Current Opinion in HIV and AIDS, 2008 - journals.lww.com
More numerous and severe primary HIV-1 infection symptoms predict more rapid disease
progression. Pooled HIV-1 RNA screening and fourth generation HIV-1 enzyme …