Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications

S Zheng, X Wang, D Zhao, H Liu, Y Hu - Trends in Cell Biology, 2023 - cell.com
Calcium ion (Ca 2+) is a ubiquitous and versatile signaling molecule controlling a wide
variety of cellular processes, such as proliferation, cell death, migration, and immune …

Therapeutic potential of natural products in treating neurodegenerative disorders and their future prospects and challenges

MH Rahman, J Bajgai, A Fadriquela, S Sharma… - Molecules, 2021 - mdpi.com
Natural products derived from plants, as well as their bioactive compounds, have been
extensively studied in recent years for their therapeutic potential in a variety of …

Recent advances in calcium‐based anticancer nanomaterials exploiting calcium overload to trigger cell apoptosis

Y Xiao, Z Li, A Bianco, B Ma - Advanced Functional Materials, 2023 - Wiley Online Library
Calcium ion is vital for the regulation of many cellular functions and serves as a second
messenger in the signal transduction pathways. Once the intracellular Ca2+ level exceeds …

Mitochondria associated membranes (MAMs): architecture and physiopathological role

L Barazzuol, F Giamogante, T Calì - Cell calcium, 2021 - Elsevier
In the last decades, the communication between the Endoplasmic reticulum (ER) and
mitochondria has obtained great attention: mitochondria-associated membranes (MAMs) …

ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport

ML Sassano, B Felipe-Abrio… - Frontiers in Cell and …, 2022 - frontiersin.org
Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural
integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange …

Balancing energy and protein homeostasis at ER-mitochondria contact sites

A Carreras-Sureda, G Kroemer, JC Cardenas… - Science Signaling, 2022 - science.org
The endoplasmic reticulum (ER) is the largest organelle of the cell and participates in
multiple essential functions, including the production of secretory proteins, lipid synthesis …

Balancing ER-mitochondrial Ca2+ fluxes in health and disease

J Loncke, A Kaasik, I Bezprozvanny, JB Parys… - Trends in cell …, 2021 - cell.com
Organelles cooperate with each other to control cellular homeostasis and cell functions by
forming close connections through membrane contact sites. Important contacts are present …

Ca2+ signaling and cell death

N Dhaouadi, VAM Vitto, P Pinton, L Galluzzi, S Marchi - Cell Calcium, 2023 - Elsevier
Multiple forms of regulated cell death (RCD) have been characterized, each of which
originates from the activation of a dedicated molecular machinery. RCD can occur in purely …

The two-way relationship between calcium and metabolism in cancer

C Dejos, D Gkika, AR Cantelmo - Frontiers in Cell and …, 2020 - frontiersin.org
Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and
subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations …

Extracellular matrix signals as drivers of mitochondrial bioenergetics and metabolic plasticity of cancer cells during metastasis

FA Urra, S Fuentes-Retamal, C Palominos… - Frontiers in cell and …, 2021 - frontiersin.org
The role of metabolism in tumor growth and chemoresistance has received considerable
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …