Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Type 1A diabetes is an organ-specific autoimmune disease resulting from destruction of
insulin-producing pancreatic β-cells. The main susceptibility genes code for polymorphic …

OBJECTIVE—The Type 1 Diabetes Genetics Consortium has collected type 1 diabetic
families worldwide for genetic analysis. The major genetic determinants of type 1 diabetes …

Objective The HLA‐DR/DQ region remains the major determinant of susceptibility to type 1
diabetes (T1D) despite the more than 50 risk affecting loci outside human leukocyte antigen …

Abstract The Banting Medal for Scientific Achievement Award is the American Diabetes
Association's highest scientific award and honors an individual who has made significant …

METHODS: In this prospective birth cohort study, 8676 children at high genetic risk of both
diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with …

Although the effects of human leukocyte antigen (HLA) locus matching on clinical outcome
in unrelated hematopoietic stem cell transplantations have been characterized, the biologic …

OBJECTIVE To determine the relative risk associated with DPA1 and DPB1 alleles and
haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of …

More than 50 years have elapsed since the association of human leukocyte antigens (HLA)
with type 1 diabetes (T1D) was first reported. Since then, methods for identification of HLA …

Background Alloimmunization or the development of alloantibodies to Red Blood Cell (RBC)
antigens is considered one of the major complications after RBC transfusions in patients …