Serine has been recently identified as an essential metabolite for oncogenesis, progression,
and adaptive immunity. Influenced by many physiologic or tumor environmental factors, the …

Metabolic changes contribute to cancer initiation and progression through effects on cancer
cells, the tumor microenvironment and whole-body metabolism. Alterations in serine …

Despite the high incidence of breast cancer in women worldwide, there are still great
challenges in the treatment process. Mitochondria are highly dynamic organelles, and their …

Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-
essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo …

Reprogramming of cancer metabolism has become increasingly concerned over the last
decade, particularly the reprogramming of glucose metabolism, also known as the" Warburg …

Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and
glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways …

Alternative splicing (AS) is necessary for viral proliferation in host cells and a critical
regulatory component of viral gene expression. Conventional RNA-seq approaches provide …

摘要目的: 探究丝氨酸生物合成途径(SSP) 关键酶磷酸丝氨酸氨基转移酶1 (PSAT1)
与肺腺癌细胞粘附的关系, 并初步探讨其作用机制. 方法: 使用siRNA 抑制PSAT1 蛋白表达 …

Adaptive metabolic switches are proposed to underlie conversions between cellular states
during normal development as well as in cancer evolution, where they represent important …

Obesity is the second leading preventable cause of cancer after tobacco smoking and it
constitutes a risk factor for breast cancer in both pre-and post-menopausal women. The …