Novel insights regarding nitric oxide and cardiovascular diseases

T Infante, D Costa, C Napoli - Angiology, 2021 - journals.sagepub.com
Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

Progress and prospects of regulatory functions mediated by nitric oxide on immunity and immunotherapy

Q Hu, J Shi, J Zhang, Y Wang, Y Guo… - Advanced …, 2021 - Wiley Online Library
Nitric oxide (NO), as a crucial signaling biomolecule, is closely involved in the
cardiovascular, immune, and central nervous system. NO not only participates in the …

[HTML][HTML] Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

W Luo, Y Wang, H Yang, C Dai, H Hong, J Li… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Aim: Premature senescence of vascular endothelial cells is a leading cause of various
cardiovascular diseases. Therapies targeting endothelial senescence would have important …

Studies on synthesis and influence of sterically driven Ni (II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity

RR Panicker, A Sivaramakrishna - Journal of Inorganic Biochemistry, 2024 - Elsevier
The present work demonstrates the synthesis, structural diversity and coordination behavior
of some selected new Ni (II)-Tpy complexes. The structural analysis revealed the …

H2S dependent and independent anti-inflammatory activity of zofenoprilat in cells of the vascular wall

M Monti, E Terzuoli, M Ziche, L Morbidelli - Pharmacological research, 2016 - Elsevier
Cardiovascular diseases as atherosclerosis are associated to an inflammatory state of the
vessel wall which is accompanied by endothelial dysfunction, and adherence and activation …

Icariin modulates eNOS activity via effect on post‐translational protein‐protein interactions to improve erectile function of spontaneously hypertensive rats

QW Liu, ZH Yang, J Jiang, R Jiang - Andrology, 2021 - Wiley Online Library
Background Type 5 phosphodiesterase inhibitor (PDE5I) has become the first‐line treatment
for erectile dysfunction (ED). However, its effective rate for hypertension ED is only 60 …

The nitric oxide donor [zn (pipnono) cl] exhibits antitumor activity through inhibition of epithelial and endothelial mesenchymal transitions

V Ciccone, A Filippelli, C Bacchella, E Monzani… - Cancers, 2022 - mdpi.com
Simple Summary Nitric oxide (NO) plays a critical pathophysiological role in cancer by
modulating several processes, such as angiogenesis, tumor growth, and metastatic …

Anti-Hypertensive Property of an NO Nanoparticle in an Adenine-Induced Chronic Kidney Disease Young Rat Model

YL Tain, HW Yang, CY Hou, GP Chang-Chien, S Lin… - Antioxidants, 2023 - mdpi.com
Hypertension is the most common complication of chronic kidney disease (CKD) in children
but is still poorly controlled. Nitric oxide (NO) deficiency plays a pivotal role in CKD and …

Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn (PipNONO) Cl

M Monti, I Hyseni, A Pacini, E Monzani… - Biochemical …, 2018 - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are now recognized as gaseous transmitters
with many cardiovascular protective properties. The present study concerns the possibility …

Antihypertensive potential of cis-[Ru (bpy) 2 (ImN)(NO)] 3+, a ruthenium-based nitric oxide donor

PPC Costa, R Campos, PHB Cabral, VM Gomes… - Research in veterinary …, 2020 - Elsevier
The aim of this study was to investigate the antihypertensive properties of cis-[Ru (bpy) 2
ImN (NO)] 3+(FOR0811) in normotensive and in N ω–nitro-L-arginine methyl ester (L-NAME) …