Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

The X-linked gene encoding MECP2 is involved in two severe and complex
neurodevelopmental disorders. Loss of function of the MeCP2 protein underlies Rett …

The proper formation and function of neuronal networks is required for cognition and
behavior. Indeed, pathophysiological states that disrupt neuronal networks can lead to …

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene
encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT …

BACKGROUND Neurodevelopmental disorders are caused by abnormalities in the
developing brain. Such abnormalities can occur as a result of germline or somatic mutations …

Rett syndrome (RTT) is an X-linked, neurodevelopmental disorder caused primarily by
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2
gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved …

Rett Syndrome is a neurodevelopmental disorder that arises from mutations in the X-linked
gene methyl-CpG binding protein 2 (MeCP2). MeCP2 has a large number of targets and a …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

The insulin-like growth factor 1 (IGF-1) signaling pathway regulates critical biological
processes including development, homeostasis, and aging. Dysregulation of this pathway …