Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Chronic kidney disease (CKD), defined as the presence of irreversible structural or
functional kidney damages, increases the risk of poor outcomes due to its association with …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that
affect chromatin-associated nuclear processes without altering the DNA sequence. With the …

Diabetic kidney disease (DKD) is one of the most common microvascular complication of
both type 1 (T1DM) and type 2 diabetes mellitus (T2DM), and the leading cause of end …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Inflammation and fibrosis are the important pathophysiologic processes in diabetic kidney
disease (DKD), which is induced by epigenetics, especially histone posttranslational …

Diabetic kidney disease (DKD) is a severe and common complication and affects a quarter
of patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation related to …