Regulation and different functions of the animal microRNA‐induced silencing complex

PM Frédérick, MJ Simard - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Among the different types of small RNAs, microRNAs (miRNAs) are key players in
controlling gene expression at the mRNA level. To be active, they must associate with an …

Cooperation and competition by RNA-binding proteins in cancer

S Nag, B Goswami, SD Mandal, PS Ray - Seminars in Cancer Biology, 2022 - Elsevier
Post-transcriptional regulation of gene expression plays a major role in determining the
cellular proteome in health and disease. Post-transcriptional control mechanisms are …

RNA-binding proteins: Underestimated contributors in tumorigenesis

Y Zhao, C Mir, Y Garcia-Mayea, R Paciucci… - Seminars in Cancer …, 2022 - Elsevier
Abstract mRNA export, translation, splicing, cleavage or capping determine mRNA stability,
which represents one of the primary aspects regulating gene expression and function. RNA …

[HTML][HTML] Diagnostic and therapeutic implications of microRNAs in non-small cell lung cancer

YH Ahn, YH Ko - International journal of molecular sciences, 2020 - mdpi.com
microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in
every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to …

[HTML][HTML] The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications

FA Khan, N Fang, W Zhang, S Ji - Cell Death & Disease, 2024 - nature.com
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as
mRNAs) post-transcriptionally through interactions with unique binding sites in the 3 …

[HTML][HTML] circNRIP1 facilitates keloid progression via FXR1‑mediated upregulation of miR‑503‑3p and miR‑503‑5p

B Wang, H Yin, H Zhang… - … Journal of Molecular …, 2021 - spandidos-publications.com
Circular nuclear receptor interacting protein 1 (circNRIP1) is implicated in tumor initiation
and progression; however, the underlying mechanism of keloid progression is unclear. To …

Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer

M Majumder, RH Johnson… - Critical reviews in …, 2020 - Taylor & Francis
The fragile X-related (FXR) family proteins FMRP, FXR1, and FXR2 are RNA binding
proteins that play a critical role in RNA metabolism, neuronal plasticity, and muscle …

[HTML][HTML] Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma

N Tanaka, C Minemura, S Asai, N Kikkawa, T Kinoshita… - Genes, 2021 - mdpi.com
Our previous study revealed that the miR-199 family (miR-199a-5p/-3p and miR-199b-5p/-
3p) acts as tumor-suppressive miRNAs in head and neck squamous cell carcinoma …

PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells<? mode longmeta?>

A Vijayakumar, M Majumder, S Yin… - Nucleic Acids …, 2024 - academic.oup.com
Emerging evidence indicates that arginine methylation promotes the stability of arginine-
glycine-rich (RGG) motif-containing RNA-binding proteins (RBPs) and regulates gene …

[HTML][HTML] FXR1 promotes proliferation, invasion and migration of hepatocellular carcinoma in vitro and in vivo

K Zhao, J Gao, J Shi, C Shi, C Pang, J Li… - Oncology …, 2023 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is a common malignancy that is associated with a poor
prognosis. The extensively studied TGF‑β pathway is mediated by SMAD proteins. FXR1, a …