Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
the offspring. The maternal immune activation hypothesis proposes that inflammatory …
Nutrition and metabolic adaptations in physiological and complicated pregnancy: focus on obesity and gestational diabetes
S Parrettini, A Caroli, E Torlone - Frontiers in endocrinology, 2020 - frontiersin.org
Pregnancy offers a window of opportunity to program the future health of both mothers and
offspring. During gestation, women experience a series of physical and metabolic …
offspring. During gestation, women experience a series of physical and metabolic …
Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial
Background Behavioural interventions might improve clinical outcomes in pregnant women
who are obese. We aimed to investigate whether a complex intervention addressing diet …
who are obese. We aimed to investigate whether a complex intervention addressing diet …
Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review
JI Mechanick, ME Farkouh, JD Newman… - Journal of the American …, 2020 - jacc.org
A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …
basis for early and sustainable, evidence-based therapeutic targeting to promote …
Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child
M Franzago, F Fraticelli, L Stuppia, E Vitacolonna - Epigenetics, 2019 - Taylor & Francis
ABSTRACT Gestational Diabetes Mellitus (GDM) is the most common metabolic condition
during pregnancy and may result in short-and long-term complications for both mother and …
during pregnancy and may result in short-and long-term complications for both mother and …
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and …
Triple-negative breast cancer (TNBC) is characterized by a more aggressive clinical course
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …
Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring
P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised …
Background Higher maternal plasma glucose (PG) concentrations, even below gestational
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …
Recent developments on the role of epigenetics in obesity and metabolic disease
The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …
problem. While genetic factors undoubtedly play a role in determining individual …