Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

Nutrition and metabolic adaptations in physiological and complicated pregnancy: focus on obesity and gestational diabetes

S Parrettini, A Caroli, E Torlone - Frontiers in endocrinology, 2020 - frontiersin.org
Pregnancy offers a window of opportunity to program the future health of both mothers and
offspring. During gestation, women experience a series of physical and metabolic …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial

L Poston, R Bell, H Croker, AC Flynn… - The lancet Diabetes & …, 2015 - thelancet.com
Background Behavioural interventions might improve clinical outcomes in pregnant women
who are obese. We aimed to investigate whether a complex intervention addressing diet …

Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers: JACC State-of-the-Art Review

JI Mechanick, ME Farkouh, JD Newman… - Journal of the American …, 2020 - jacc.org
A new cardiometabolic-based chronic disease (CMBCD) model is presented that provides a
basis for early and sustainable, evidence-based therapeutic targeting to promote …

Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child

M Franzago, F Fraticelli, L Stuppia, E Vitacolonna - Epigenetics, 2019 - Taylor & Francis
ABSTRACT Gestational Diabetes Mellitus (GDM) is the most common metabolic condition
during pregnancy and may result in short-and long-term complications for both mother and …

Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and …

X Bao, R Shi, T Zhao, Y Wang, N Anastasov… - Cancer Immunology …, 2021 - Springer
Triple-negative breast cancer (TNBC) is characterized by a more aggressive clinical course
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised …

E Antoun, NT Kitaba, P Titcombe, KV Dalrymple… - PLoS …, 2020 - journals.plos.org
Background Higher maternal plasma glucose (PG) concentrations, even below gestational
diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with …

Recent developments on the role of epigenetics in obesity and metabolic disease

SJ van Dijk, RL Tellam, JL Morrison, BS Muhlhausler… - Clinical …, 2015 - Springer
The increased prevalence of obesity and related comorbidities is a major public health
problem. While genetic factors undoubtedly play a role in determining individual …