Mood, attention and motivation co-vary with activity in the neuromodulatory systems of the
brain to influence behaviour. These psychological states, mediated by neuromodulators …

The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout
the brain via widespread efferent projections, and plays a pivotal role in modulating …

Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …

A central question about human brain aging is whether cognitive enrichment slows the
development of Alzheimer changes. Here, we show that prolonged exposure to an enriched …

Noradrenaline (NA) is a key neuromodulator for the regulation of behavioral state and
cognition. It supports learning by increasing arousal and vigilance, whereby new …

J. Neurochem.(2010) 113, 649–660. Abstract Degeneration of locus coeruleus (LC)
noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The …

Memory consolidation is enhanced by emotional arousal, an effect mediated by
noradrenergic beta-receptor signaling. Norepinephrine strengthens consolidation of both …

The neuromodulator noradrenaline (NA) is released in almost all brain areas in a highly
diffused manner. Its action is slow, as it acts through G protein-coupled receptors, but its …

Protein kinase A (PKA) plays multiple roles in neurons. The localization and specificity of
PKA are largely controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics …

Heart failure (HF) is a major public health issue affecting more than 26 million people
worldwide. HF is the most common cardiovascular disease in elder population; and it is …