Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …

Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …

Exploitation of recombinant DNA and sequencing technologies has led to a new concept in
vaccination in which isolated epitopes, capable of stimulating a specific immune response …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

Antibody-antigen binding relies on the specific interaction of amino acids at the paratope-
epitope interface. The predictability of antibody-antigen binding is a prerequisite for de novo …

Background Reliable prediction of antibody, or B-cell, epitopes remains challenging yet
highly desirable for the design of vaccines and immunodiagnostics. A correlation between …

The identification and characterization of B‐cell epitopes play an important role in vaccine
design, immunodiagnostic tests, and antibody production. Therefore, computational tools for …

Motivation: Discovery of novel protective antigens is fundamental to the development of
vaccines for existing and emerging pathogens. Most computational methods for predicting …

The only part of an antigen (a protein molecule found on the surface of a pathogen) that is
composed of epitopes specific to T and B cells is recognized by the human immune system …