Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

During the last decades, lipids have gained much attention due to their involvement in
health and disease. Lipids are required for the formation of membranes and contribute to …

Niemann-Pick disease type C (NPC) is associated with mutations in NPC1 and NPC2,
whose gene products are key players in the endosomal/lysosomal egress of low-density …

Abstract Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage
disorder caused by mutations in the acidic compartment (which we define as the late …

Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from
endogenous biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the …

Oxysterol-binding protein (OSBP) and its related proteins (ORPs) constitute a large and
evolutionarily conserved family of lipid-binding proteins that target organelle membranes to …

Understanding how membrane lipids achieve their non-random distribution in cells is a key
challenge in cell biology at present. In addition to being sorted into vesicles that can cross …

Ergosterol, an important component of the fungal cell membrane, is not only essential for
fungal growth and development but also very important for adaptation to stress in fungi …

Summary Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis,
believed to drive sterol integration into the lysosomal membrane before redistribution to …

Abstract Niemann-Pick type C (NPC) disease is a lysosomal storage disease (LSD)
characterized by the buildup of endo-lysosomal cholesterol and glycosphingolipids due to …