Fc receptors (FcRs) belong to the ITAM-associated receptor family. FcRs control the humoral
and innate immunity which are essential for appropriate responses to infections and …

A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

Anti–glomerular basement membrane (anti-GBM) disease is a rare small vessel vasculitis
that affects the capillary beds of the kidneys and lungs. It is an archetypic autoimmune …

FcγRIIB is the only inhibitory Fc receptor. It controls many aspects of immune and
inflammatory responses, and variation in the gene encoding this protein has long been …

Systemic lupus erythematosus is a prototypic autoimmune disease characterized by
autoantibody production and immune complex formation/deposition in target organs such as …

Intravenous IgG (IVIg) contains polyclonal immunoglobulin G (IgG) from thousands of
donors. It is administered at a low dose at regular intervals as antibody replacement therapy …

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

The biological activities of human IgG antibodies predominantly rely on a family of receptors
for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5 …

Monoclonal antibodies (mAbs) are currently the largest and most dominant class of
therapeutic proteins. Inter-individual variability has been observed for several mAbs; …

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …