Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

Tumor necrosis factor receptor (TNFR)‐associated factor 6 (TRAF 6) is an adapter protein
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …

Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint
blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages …

Persistent infection by EBV is explained by the germinal center model (GCM) which provides
a satisfying and currently the only explanation for EBVs disparate biology. Since the GCM …

Although a fraction of human blood memory CD4+ T cells expresses chemokine (CXC motif)
receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well established …

Follicular helper T cells (TFH cells) compose a heterogeneous subset of CD4+ T cells that
induce the differentiation of B cells into plasma cells and memory cells. They are found …

B cells are regarded for their capacity to produce antibody. However, recent advances in B
cell biology have capitalized on old findings and demonstrated that B cells also release a …

Our understanding of the origin and functions of human blood CXCR5+ CD4+ T cells found
in human blood has changed dramatically in the past years. These cells are currently …

Type 1 conventional dendritic cells (cDC1s) are typically thought to be dysregulated
secondarily to invasive cancer. Here, we report that cDC1 dysfunction instead develops in …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …