Acetate production from glucose and coupling to mitochondrial metabolism in mammals
Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …
Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation
KM Dorighi, T Swigut, T Henriques, NV Bhanu… - Molecular cell, 2017 - cell.com
Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …
Acetyl-CoA metabolism supports multistep pancreatic tumorigenesis
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for
prevention and treatment are urgently needed. We previously reported that histone H4 …
prevention and treatment are urgently needed. We previously reported that histone H4 …
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …
one of the most frequently mutated genes in follicular lymphoma and diffuse large B cell …
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of
incredible specificity in transmitting signals involved in cellular function, including germ cell …
incredible specificity in transmitting signals involved in cellular function, including germ cell …
Capturing the onset of PRC2-mediated repressive domain formation
Summary Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing
methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a …
methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a …
Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry
Highlights•A useful reference for quantitative analysis of histone modifications.•Three
general approaches to analyze histone modifications by mass spectrometry.•Analytical …
general approaches to analyze histone modifications by mass spectrometry.•Analytical …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
Targeting CDK9 reactivates epigenetically silenced genes in cancer
H Zhang, S Pandey, M Travers, H Sun, G Morton… - Cell, 2018 - cell.com
Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
Posterior fossa type A (PFA) ependymomas exhibit very low H3K27 methylation and express
high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein, also termed …
high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein, also termed …