Stress has a critical role in the development and expression of many psychiatric disorders,
and is a defining feature of posttraumatic stress disorder (PTSD). Stress also limits the …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

“A rigorous, in-depth guide to the history, philosophy, and scientific exploration of this
widespread emotional state...[LeDoux] offers a magisterial review of the role of mind and …

Fear extinction is an adaptive process whereby defensive responses are attenuated
following repeated experience of prior fear-related stimuli without harm. The formation of …

Deep brain stimulation (DBS) has improved the prospects for many individuals with
diseases affecting motor control, and recently it has shown promise for improving cognitive …

The measurement of Pavlovian forms of fear extinction offers a relatively simple behavioral
preparation that is nonetheless tractable, from a translational perspective, as an approach to …

The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …

Schizophrenia is considered primarily as a cognitive disorder. However, functional
outcomes in schizophrenia are limited by the lack of effective pharmacological and …

Posttraumatic stress disorder manifests after exposure to a traumatic event and is
characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and …