Plasmonic nanoparticles in biomedicine

WQ Lim, Z Gao - Nano Today, 2016 - Elsevier
The use of plasmonic nanoparticles for biomedical applications has been extensively
researched, yielding significant advancements in the construction of ultrasensitive bioassays …

Laser-assisted photoporation: fundamentals, technological advances and applications

R Xiong, SK Samal, J Demeester… - … in Physics: X, 2016 - Taylor & Francis
Laser-assisted photoporation is a promising technique that is receiving increasing attention
for the delivery of membrane impermeable nanoscopic substances into living cells …

Characterization of nanoparticle mediated laser transfection by femtosecond laser pulses for applications in molecular medicine

M Schomaker, D Heinemann, S Kalies… - Journal of …, 2015 - Springer
Background In molecular medicine, the manipulation of cells is prerequisite to evaluate
genes as therapeutic targets or to transfect cells to develop cell therapeutic strategies. To …

Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles

L Gentemann, S Kalies, M Coffee, H Meyer… - Biomedical optics …, 2016 - opg.optica.org
Can photothermal gold nanoparticle mediated laser manipulation be applied to induce
cardiac contraction? Based on our previous work, we present a novel concept of cell …

Can titanium oxide nanotubes facilitate intracellular delivery by laser-assisted photoporation?

L Mohan, S Kar, R Hattori, M Ishii-Teshima, P Bera… - Applied Surface …, 2021 - Elsevier
In the present study, a newly developed nanosecond pulse laser-assisted photoporation
using titanium-oxide nanotubes (TNT) for highly efficient intracellular delivery has been …

Femtosecond Plasmonic Laser Nanosurgery (fs-PLN) mediated by molecularly targeted gold nanospheres at ultra-low pulse fluences

D Eversole, K Subramanian, RK Harrison… - Scientific Reports, 2020 - nature.com
Abstract Plasmonic Laser Nanosurgery (PLN) is a novel photomodification technique that
exploits the near-field enhancement of femtosecond (fs) laser pulses in the vicinity of gold …

Delivery of proteins to mammalian cells via gold nanoparticle mediated laser transfection

D Heinemann, S Kalies, M Schomaker… - …, 2014 - iopscience.iop.org
Nanoparticle laser interactions are in widespread use in cell manipulation. In particular,
molecular medicine needs techniques for the directed delivery of molecules into mammalian …

Laser‐assisted nucleic acid delivery: A systematic review

S Hosseinpour, LJ Walsh - Journal of Biophotonics, 2021 - Wiley Online Library
Gene therapy has become an effective treatment modality for some conditions. Laser light
may augment or enhance gene therapy through photomechanical, photothermal, and …

Analysis of poration-induced changes in cells from laser-activated plasmonic substrates

N Saklayen, S Kalies, M Madrid, V Nuzzo… - Biomedical optics …, 2017 - opg.optica.org
Laser-exposed plasmonic substrates permeabilize the plasma membrane of cells when in
close contact to deliver cell-impermeable cargo. While studies have determined the cargo …

Nanoparticle-Mediated Photoporation: Expanding Horizons in Drug Delivery

E McGraw, GM Laurent, LA Avila - Nanoscale Advances, 2024 - pubs.rsc.org
Facilitating the delivery of impermeable molecules into cells stands as a pivotal step for both
basic research and therapeutic delivery. While current methods predominantly use …