The kynurenine pathway: a finger in every pie
J Savitz - Molecular psychiatry, 2020 - nature.com
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …
Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
K Hashimoto - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders.
Approximately one‐third of the patients with MDD are treatment resistant to the current …
Approximately one‐third of the patients with MDD are treatment resistant to the current …
The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies
The importance of tryptophan as a precursor for neuroactive compounds has long been
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …
acknowledged. The metabolism of tryptophan along the kynurenine pathway and its …
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression
E Haroon, JR Welle, BJ Woolwine… - …, 2020 - nature.com
Kynurenine pathway (KP) metabolites are believed to be a link between inflammation and
depression through effects on brain glutamate receptors. However, neither the relationship …
depression through effects on brain glutamate receptors. However, neither the relationship …
Inflammation, stress and depression: an exploration of ketamine's therapeutic profile
Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …
Ketamine and serotonergic psychedelics: an update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment
The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …
understand its underlying mechanisms of action and to identify other novel compounds that …
Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis
Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …
produce rapid and substantial antidepressant effects. However, individual response to …
The kynurenine pathway in major depression: What we know and where to next
Major depression is a serious psychiatric disorder, occurring in up to 20% of the population.
Despite its devastating burden, the neurobiological changes associated with depression are …
Despite its devastating burden, the neurobiological changes associated with depression are …
Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications
Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
An update on ketamine and its two enantiomers as rapid-acting antidepressants
K Zhang, K Hashimoto - Expert review of neurotherapeutics, 2019 - Taylor & Francis
Introduction: Depression is one of the most disabling diseases worldwide. Approximately
one-third of depressed patients are treatment-resistant to the currently available …
one-third of depressed patients are treatment-resistant to the currently available …