Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

Intestinal immune cell trafficking has been identified as a central event in the pathogenesis
of inflammatory bowel diseases (IBD). Intensive research on different aspects of the immune …

The peptidergic system is the most abundant network of ligand-receptor-mediated signaling
in humans. However, the physiological roles remain elusive for numerous peptides and …

The principal targets for anti-chemokine therapy in inflammatory bowel disease (IBD) have
been the receptors CCR9 and CXCR3 and their respective ligands CCL25 and CXCL10 …

G protein-coupled receptors (GPCRs) are usually highlighted as being both the largest
family of membrane proteins and the most productive source of drug targets. However, most …

Abstract Background and Aims The “gut homing” hypothesis suggests the pathogenesis of
primary sclerosing cholangitis (PSC) is driven by aberrant hepatic expression of gut …

Integrins are cell surface receptors with bidirectional signalling capabilities that can bind to
adhesion molecules in order to mediate homing of leukocytes to peripheral tissues. Gut …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for
many types of cancer. Genetic disparities between donor and host can result in immune …

Environmental factors are the major contributor to the onset of immunological disorders such
as ulcerative colitis. However, their identities remain unclear. Here, we discover that the …

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis
(UC) are multifactorial diseases with still unknown aetiology and an increasing prevalence …