From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

Background Castration-resistant prostate cancer (CRPC) occurs when prostate cancer
(CaP) progresses under therapy-induced castrate conditions. Several mechanisms have …

Chronic inflammation and an immunosuppressive microenvironment promote prostate
cancer (PCa) progression and diminish the response to immune checkpoint blockade (ICB) …

Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa)
is a major factor contributing to its lethality, although the mechanisms remain poorly …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway.
Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype
of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

The role of dysregulation of mRNA alternative splicing (AS) in the development and
progression of solid tumors remains to be defined. Here we describe the first comprehensive …