[HTML][HTML] Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

J Dos Santos, GS da Silva, MC Velho, RCR Beck - Pharmaceutics, 2021 - mdpi.com
Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the
development of modified drug delivery systems. They are widely known due to their …

Systematic screening of pharmaceutical polymers for hot melt extrusion processing: A comprehensive review

R Thakkar, R Thakkar, A Pillai, EA Ashour… - International journal of …, 2020 - Elsevier
Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

Role of release modifiers to modulate drug release from fused deposition modelling (FDM) 3D printed tablets

K Shi, JP Salvage, M Maniruzzaman… - International journal of …, 2021 - Elsevier
Although hot melt extrusion (HME) has been used in combination with fused deposition
modelling (FDM) three-dimensional printing (3DP), suitable feedstock materials such as …

[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Novel strategies for the formulation and processing of poorly water-soluble drugs

K Göke, T Lorenz, A Repanas, F Schneider… - European Journal of …, 2018 - Elsevier
Low aqueous solubility of active pharmaceutical ingredients presents a serious challenge in
the development process of new drug products. This article provides an overview on some …

Development of a hot-melt extrusion (HME) process to produce drug loaded Affinisol™ 15LV filaments for fused filament fabrication (FFF) 3D printing

E Prasad, MT Islam, DJ Goodwin, AJ Megarry… - Additive …, 2019 - Elsevier
The aim of the present work was to develop a pilot scale process to produce drug-loaded
filaments for 3D printing of oral solid dose forms by fused filament fabrication (FFF). Using …

Physical stability of amorphous solid dispersions: a physicochemical perspective with thermodynamic, kinetic and environmental aspects

X Lin, Y Hu, L Liu, L Su, N Li, J Yu, B Tang… - Pharmaceutical …, 2018 - Springer
Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Molecular insight into drug-loading capacity of PEG–PLGA nanoparticles for itraconazole

N Wilkosz, G Łazarski, L Kovacik… - The Journal of …, 2018 - ACS Publications
Nanoparticles made of amphiphilic block copolymers comprising biodegradable core-
forming blocks are very attractive for the preparation of drug-delivery systems with sustained …

[HTML][HTML] Analytical and computational methods for the estimation of drug-polymer solubility and miscibility in solid dispersions development

D Medarević, J Djuriš, P Barmpalexis, K Kachrimanis… - Pharmaceutics, 2019 - mdpi.com
The development of stable solid dispersion formulations that maintain desired improvement
of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer …

Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus® processed by hot melt extrusion

AB Albadarin, CB Potter, MT Davis, J Iqbal… - International journal of …, 2017 - Elsevier
The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose
phthalate (HPMCP-HP-50) and Soluplus® polymers for enhanced physicochemical stability …