Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in
terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has …

Approximately half of the patients diagnosed with oesophageal cancer present with
unresectable or metastatic disease. Treatment for these patients aims to control dysphagia …

PURPOSE To analyze the effect of radiation dose escalation to the primary tumor on local
tumor control in definitive chemoradiation (dCRT) for patients with esophageal cancer …

Importance The role of epidermal growth factor receptor (EGFR) inhibition in chemoradiation
strategies in the nonoperative treatment of patients with esophageal cancer remains …

Importance Multiple paclitaxel-based regimens are widely used in chemoradiation therapy
against esophageal cancer, including regimens combining paclitaxel with fluorouracil …

Background The utility of early metabolic response assessment to guide selection of the
systemic component of definitive chemoradiotherapy (dCRT) for oesophageal cancer is …

Cancer-associated fibroblasts (CAFs), an activated subpopulation of fibroblasts, occupy a
central position in the tumor microenvironment and have been shown to promote …

Esophageal cancer (EC) is one of the most incident and lethal tumors worldwide. Although
surgical resection is an important approach in EC treatment, late diagnosis, metastasis and …

We investigate whether high-dose (HD,≥ 60 Gy) radiotherapy in definitive concurrent
chemoradiotherapy (CCRT) based on cisplatin could yield benefits compared to …

Members of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family function as
the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their …