Retinoid X receptor: cellular and biochemical roles of nuclear receptor with a focus on neuropathological involvement
Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with
particularly high evolutionary conservation of ligand binding domain. The receptor exists in …
particularly high evolutionary conservation of ligand binding domain. The receptor exists in …
[HTML][HTML] Up-to-date molecular medicine strategies for management of ocular surface neovascularization
Ocular surface neovascularization and its resulting pathological changes significantly alter
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …
Immune-Goblet cell interaction in the conjunctiva
J Alam, CS de Paiva, SC Pflugfelder - The ocular surface, 2020 - Elsevier
The conjunctiva is a goblet cell rich mucosal tissue. Goblet cells are supported by tear
growth factors and IL-13 produced by resident immune cells. Goblet cell secretions are …
growth factors and IL-13 produced by resident immune cells. Goblet cell secretions are …
Eggshell membrane modulates gut microbiota to prevent murine pre‐cachexia through suppression of T helper cell differentiation
H Jia, W Lyu, K Hirota, E Saito… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Cachexia is a life‐threatening condition observed in several pathologies, such
as cancer or chronic diseases. Interleukin 10 (Il10) gene transfer is known to improve …
as cancer or chronic diseases. Interleukin 10 (Il10) gene transfer is known to improve …
MicroRNAs in the cornea: Role and implications for treatment of corneal neovascularization
With no safe and efficient approved therapy available for treating corneal
neovascularization, the search for alternative and effective treatments is of great importance …
neovascularization, the search for alternative and effective treatments is of great importance …
Recent approaches for angiogenesis in search of successful tissue engineering and regeneration
Angiogenesis plays a central role in human physiology from reproduction and fetal
development to wound healing and tissue repair/regeneration. Clinically relevant therapies …
development to wound healing and tissue repair/regeneration. Clinically relevant therapies …
[HTML][HTML] Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression …
Purpose To evaluate conjunctival cell microRNA (miRNAs) and mRNA expression in
relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of …
relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of …
Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis
Background The ways in which microglia activate and promote neovascularization (NV) are
not fully understood. Recent in vivo evidence supports the theory that calcium is required for …
not fully understood. Recent in vivo evidence supports the theory that calcium is required for …
MMP12 inhibits corneal neovascularization and inflammation through regulation of CCL2
Following corneal injury, coordinated cellular and protein interactions occur at the wound
site to restore tissue homeostasis. Regulation of this response is required to prevent the …
site to restore tissue homeostasis. Regulation of this response is required to prevent the …
Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors
J Lappalainen, N Yeung, SD Nguyen, M Jauhiainen… - Scientific reports, 2021 - nature.com
In atherosclerotic lesions, blood-derived monocytes differentiate into distinct macrophage
subpopulations, and further into cholesterol-filled foam cells under a complex milieu of …
subpopulations, and further into cholesterol-filled foam cells under a complex milieu of …