Recognition of target site in various forms of DNA and RNA by peptide nucleic acid (PNA): From fundamentals to practical applications
X Liang, M Liu, M Komiyama - Bulletin of the Chemical Society of …, 2021 - academic.oup.com
Peptide nucleic acid (PNA) is a DNA analog, in which the sugar-phosphate backbone in
DNA is replaced by poly [N-(2-aminoethyl) glycine]. Since its discovery in the early 1990s …
DNA is replaced by poly [N-(2-aminoethyl) glycine]. Since its discovery in the early 1990s …
Composite 5-methylations of cytosines modulate i-motif stability in a sequence-specific manner: Implications for DNA nanotechnology and epigenetic regulation of …
P Školáková, Z Badri, S Foldynová-Trantírková… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Background The i-motif is a tetrameric DNA structure based on the formation of
hemiprotonated cytosine-cytosine (C+. C) base pairs. i-motifs are widely used in …
hemiprotonated cytosine-cytosine (C+. C) base pairs. i-motifs are widely used in …
Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach
M Moccia, FA Mercurio, E Langella, V Piacenti… - Frontiers in …, 2020 - frontiersin.org
In the present work, structural features of the interaction between peptide nucleic acid (PNA)-
based analogs of the tumor-suppressor microRNA-34a with both its binding sites on MYCN …
based analogs of the tumor-suppressor microRNA-34a with both its binding sites on MYCN …
6 Nucleic acids quadruplex
DNA is mostly in the form of a double helix. However, in G-rich regions DNA can adopt other
three-dimensional structures such as the G-quadruplex (G4), a structure formed by guanine …
three-dimensional structures such as the G-quadruplex (G4), a structure formed by guanine …
Aptamer-nanosilver conjugates and their antibacterial activity
J Soundy - 2019 - openaccess.wgtn.ac.nz
The rise of antibiotic resistance in bacteria constitutes one of the greatest emerging threats
to human health that requires the urgent development of new drugs and treatment …
to human health that requires the urgent development of new drugs and treatment …