Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of
hematologic malignancies, particularly pediatric leukemias with poor patient outcomes …

Targeted therapy for acute myeloid leukemia (AML) is an effective strategy, but currently
there are very limited therapeutic targets for AML treatment. Histone lysine specific …

NUP98 fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98
fusion proteins share an intrinsically disordered region (IDR) in the NUP98 N terminus …

Proper subcellular localization is crucial for the functioning of biomacromolecules, including
proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the …

Pediatric acute myeloid leukemia (AML) develops from clonal expansion of hematopoietic
precursor cells and is characterized by morphologic and cytomolecular heterogeneity …

Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …

Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …

Chromosomal translocations involving the NUP98 locus are among the most prevalent
rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is …

Objectives The cryptic fusion oncogene NUP98:: NSD1 is known to be associated with FLT3‐
ITD mutation in acute myeloid leukemia (AML), and an independent poor prognostic factor in …

Abstract RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid
leukaemia. Seminal contributions by many different research groups have revealed a …