Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

Autoimmune diseases affect tens of millions of people just in the United States alone. Most
of the available treatment options are aimed at reducing symptoms but do not lead to cures …

The immunomodulatory family of Siglecs recognizes sialic acid-containing glycans as “self”,
which is exploited in cancer for immune evasion. The biochemical nature of Siglec ligands …

The sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed predominantly
on white blood cells and participate in immune cell recognition of self. Most Siglecs contain …

Upregulation of surface expressed sialoglycans on tumor cells is one of the mechanisms
which promote tumor growth and progression. Specifically, the interactions of sialic acids …

The CD24 protein is a heat-stable protein with a small core that undergoes extensive
glycosylation. It is expressed on the surface of various normal cells, including lymphocytes …

Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …

Tumor-associated macrophages (TAMs) in the tumor microenvironment potentially enhance
tumor growth and invasion through various mechanisms and are thus an essential factor in …

Malignant tumors are complex structures composed of cancer cells and tumor
microenvironmental cells. In this complex structure, cells cross-talk and interact, thus jointly …

Simple Summary This work reviews the role of aberrant glycosylation in cancer cells during
tumour growth and spreading, as well as in immune evasion. The interaction of tumour …