Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract
cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of …

Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …

Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To
develop targeted treatments, it is important to understand the transcriptomic consequences …

Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. Despite advances in therapeutic management and immunotherapy, the 5-year …

Nuclear receptor binding SET Domain Protein 1 (NSD1) is a bifunctional transcriptional
regulatory protein that encodes histone methyltransferase. Mono-and di-methylation of …

Background Oral squamous cell carcinoma (OSCC), as the most common oral cancer
globally, is very harmful to people's health. Hypoxia is closely related to many cancers. In …

Simple Summary This study identified the PIP4K2B protein as a key target of NSD1 in head
and neck cancer. We found that PIP4K2B positively regulates the mTOR signaling pathway …

In head and neck squamous cell carcinoma (HNSCC), a significant proportion of tumors
have inactivating mutations in the histone methyltransferase NSD1. In these tumors, NSD1 …

Simple Summary High levels of global genome methylation in HPV-associated head and
neck cancer prompted us to explore demethylation as a potential treatment by determining …