Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Behavioral phenotyping has been gaining prominence due to the increased use of
transgenic animal models of neurological disorders. Repeated testing in the same cohort of …

Background: Reboxetine is a potent antidepressant, with efficacy comparable to that of
imipramine, desipramine, and fluoxetine, and has improved side-effect profile. The basis of …

The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Inhibition of the serotonin transporter (5-HTT) is a principal initial target of many
antidepressants. However, the contribution of the 5-HTT to their therapeutic efficacy is …

Background and purpose: The present study evaluated the role of CB2 receptors in the
regulation of depressive‐like behaviours. Transgenic mice overexpressing the CB2 receptor …

The anxiolytic and antidepressant properties of cannabidiol (CBD) have been evaluated in
several studies. However, the molecular mechanisms involved in these actions remain …

Several studies have reported rodent strain differences in the response to antidepressants in
animal models of depression. The aim of the present study was to investigate the potential …

Affective disorders such as major depression are among the most prevalent and costly
diseases of the central nervous system, but the underlying mechanisms are still poorly …

Depression is a growing pandemic in developed societies. The use of inbred mouse strains
in pre-clinical psychiatric research has proven to be a valuable resource. Firstly, they …