Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Histones package and compact DNA by assembling into nucleosome core particles. Most
histones are synthesized at S phase for rapid deposition behind replication forks. In addition …

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …

Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …

Histones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant
histones have evolved crucial roles in chromosome segregation, transcriptional regulation …

INO80 is an evolutionarily conserved, ATP-dependent chromatin-remodeling enzyme that
plays roles in transcription, DNA repair, and replication. Here, we show that yeast INO80 …

The regulation of eukaryotic chromatin relies on interactions between many epigenetic
factors, including histone modifications, DNA methylation, and the incorporation of histone …

Chromatin remodeling during DNA double-strand break (DSB) repair is required to facilitate
access to and repair of DSBs. This remodeling requires increased acetylation of histones …

Eukaryotic chromatin is separated into functional domains differentiated by post-translational
histone modifications, histone variants and DNA methylation,,,,,. Methylation is associated …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …