Integrin activation by talin, kindlin and mechanical forces
Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …
extracellular matrix. They are essential for embryonic development and influence numerous …
Cell adhesion by integrins
M Bachmann, S Kukkurainen… - Physiological …, 2019 - journals.physiology.org
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …
between cells and the extracellular matrix. In addition to the anchorage of cells to the …
Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
Talins and kindlins: partners in integrin-mediated adhesion
DA Calderwood, ID Campbell… - Nature reviews Molecular …, 2013 - nature.com
Integrin receptors provide a dynamic, tightly-regulated link between the extracellular matrix
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …
(or cellular counter-receptors) and intracellular cytoskeletal and signalling networks …
[HTML][HTML] Talin as a mechanosensitive signaling hub
Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …
Extracellular rigidity sensing by talin isoform-specific mechanical linkages
K Austen, P Ringer, A Mehlich, A Chrostek-Grashoff… - Nature cell …, 2015 - nature.com
The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ
development and function. The central mechanisms by which adherent cells detect …
development and function. The central mechanisms by which adherent cells detect …
Crosstalk between cell adhesion complexes in regulation of mechanotransduction
A Zuidema, W Wang, A Sonnenberg - Bioessays, 2020 - Wiley Online Library
Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …
and pathology. Forces between the external environment and intracellular actin cytoskeleton …
Mechanisms of integrin activation and trafficking
C Margadant, HN Monsuur, JC Norman… - Current opinion in cell …, 2011 - Elsevier
Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array …
organisms, and defective integrin activation or integrin signaling is associated with an array …
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
Integrins in focal adhesions (FAs) mediate adhesion and force transmission to extracellular
matrices essential for cell motility, proliferation and differentiation. Different fibronectin …
matrices essential for cell motility, proliferation and differentiation. Different fibronectin …
Intrinsically disordered proteins play diverse roles in cell signaling
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …