[HTML][HTML] Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
LHM Geraldo, TCLS Spohr, RF Amaral… - Signal transduction and …, 2021 - nature.com
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions
both in development and in pathological conditions. Here, we review the literature about the …
both in development and in pathological conditions. Here, we review the literature about the …
[HTML][HTML] The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective
The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …
superfamily of small GTPases and is involved in a wide variety of physiological processes …
[HTML][HTML] CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway
J Pan, Z Fan, Z Wang, Q Dai, Z Xiang, F Yuan… - Journal of Experimental …, 2019 - Springer
Background Gastric cancer (GC) has a clear predilection for metastasis toward the omentum
which is primarily composed of adipose tissue, indicating that fatty acids may contribute to …
which is primarily composed of adipose tissue, indicating that fatty acids may contribute to …
LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction
J Pei, L Cai, F Wang, C Xu, S Pei, H Guo… - Circulation …, 2022 - Am Heart Assoc
Rationale: Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular
events. Our previous study found that lysophosphatidic acid (LPA) is increased in human …
events. Our previous study found that lysophosphatidic acid (LPA) is increased in human …
ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
S Hashimoto, S Furukawa… - Proceedings of the …, 2019 - National Acad Sciences
Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma
(PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its …
(PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its …
[HTML][HTML] Down-regulation of BMAL1 by MiR-494-3p promotes hepatocellular carcinoma growth and metastasis by increasing GPAM-mediated lipid biosynthesis
Y Yang, T Yang, Z Zhao, H Zhang, P Yuan… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The circadian clock confers daily rhythmicity to many crucial biological processes and
behaviors and its disruption is closely associated with carcinogenesis in several types of …
behaviors and its disruption is closely associated with carcinogenesis in several types of …
[HTML][HTML] Lysophosphatidic acid receptor antagonists and cancer: the current trends, clinical implications, and trials
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled …
[HTML][HTML] DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han… - Oncogene, 2022 - nature.com
Abstract Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase
family, and its ligand is collagen. Previous studies demonstrated that DDR1 is highly …
family, and its ligand is collagen. Previous studies demonstrated that DDR1 is highly …
Roles of Arf6 in cancer cell invasion, metastasis and proliferation
R Li, C Peng, X Zhang, Y Wu, S Pan, Y Xiao - Life sciences, 2017 - Elsevier
Abstract ADP-ribosylation factor 6 (Arf6), a member of small GTPases ADP-ribosylation
factor (Arf) family, expresses widely in mammalian cells and mainly regulates the functions …
factor (Arf) family, expresses widely in mammalian cells and mainly regulates the functions …
[HTML][HTML] Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
Y Onodera, JM Nam, M Horikawa, H Shirato… - Nature …, 2018 - nature.com
Mitochondria dynamically alter their subcellular localization during cell movement, although
the underlying mechanisms remain largely elusive. The small GTPase Arf6 and its signaling …
the underlying mechanisms remain largely elusive. The small GTPase Arf6 and its signaling …