Modulating protein–protein interactions involved in disease pathways is an attractive
strategy for developing drugs, but remains a challenge to achieve. One approach is to target …

In addition to powering energy needs of the cell, mitochondria function as pivotal integrators
of cell survival/death signals. In recent years, numerous studies indicate that each of the …

Protein kinase C (PKC) family members transduce an abundance of diverse intracellular
signals. Here we address the role of spatial and temporal segregation in signal specificity by …

Mitochondria play a central role in the regulation of programmed cell death signaling. Here,
we report the finding of a mitochondrial matrix-targeted protein phosphatase 2C family …

It has become appreciated over the last several years that protein phosphorylation within the
cardiac mitochondrial matrix and respiratory complexes is extensive. Given the importance …

PICK1 is a peripheral membrane protein conserved from Caenorhabditis elegans to the
human. It is expressed in many tissues with high levels in brain and testis. Inside cells …

Mitochondria are highly integrated organelles that are crucial to cell adaptation and
mitigating adverse physiology. Recent studies demonstrate that fundamental signal …

Abstract TIS21/BTG2/PC3, orthologs of mouse, human and rat, respectively, is initially
identified as one of the early growth response genes and induced by various stimulations …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …

More than two decades ago, the discovery of the first C2 domain in conventional Protein
Kinase Cs (cPKCs) and of its role as a calcium-binding motif began to shed light on the …