Membrane active peptides and their biophysical characterization

FG Avci, B Sariyar Akbulut, E Ozkirimli - Biomolecules, 2018 - mdpi.com
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …

How random are intrinsically disordered proteins? A small angle scattering perspective

V Receveur-Bréchot, D Durand - Current Protein and Peptide …, 2012 - ingentaconnect.com
While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …

Role of Tat protein in HIV neuropathogenesis

W Li, G Li, J Steiner, A Nath - Neurotoxicity research, 2009 - Springer
The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …

Didehydro-cortistatin A inhibits HIV-1 by specifically binding to the unstructured basic region of Tat

S Mediouni, K Chinthalapudi, MK Ekka, I Usui… - MBio, 2019 - Am Soc Microbiol
The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response
structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression …

Clade‐specific differences in neurotoxicity of human immunodeficiency virus‐1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

M Mishra, S Vetrivel, NB Siddappa… - Annals of …, 2008 - Wiley Online Library
Objective Human immunodeficiency virus‐1 (HIV‐1) causes mild to severe cognitive
impairment and dementia. The transactivator viral protein, Tat, is implicated in neuronal …

HIV-1 Tat is a natively unfolded protein: the solution conformation and dynamics of reduced HIV-1 Tat-(1–72) by NMR spectroscopy

S Shojania, JD O'Neil - Journal of Biological Chemistry, 2006 - ASBMB
Tat (transactivator of transcription) is a small RNA-binding protein that plays a central role in
the regulation of human immunodeficiency virus type 1 replication and in approaches to …

HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review

PT Gotora, R van der Sluis, ME Williams - BMC Infectious Diseases, 2023 - Springer
HIV-1 remains a global health concern and to date, nearly 38 million people are living with
HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by …

The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis

GR Campbell, E Pasquier, J Watkins… - Journal of Biological …, 2004 - ASBMB
Human immunodeficiency virus (HIV) infection and the progression to AIDS are
characterized by the depletion of CD4+ T-cells. HIV-1 infection leads to apoptosis of …

What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?

GR Campbell, EP Loret - Retrovirology, 2009 - Springer
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat
is an important factor in viral pathogenesis. In addition to its function as the key trans …

Characterizing the interactions of cell-membrane-disrupting peptides with lipid-functionalized single-walled carbon nanotubes

A Yadav, P Kelich, N Kallmyer, NF Reuel… - ACS applied materials …, 2023 - ACS Publications
Lipid-functionalized single-walled carbon nanotubes (SWNTs) have garnered significant
interest for their potential use in a wide range of biomedical applications. In this work, we …