Membrane active peptides and their biophysical characterization
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …
active peptides. These peptides exert their biological activity by interacting with the cell …
How random are intrinsically disordered proteins? A small angle scattering perspective
V Receveur-Bréchot, D Durand - Current Protein and Peptide …, 2012 - ingentaconnect.com
While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …
recognized, deciphering their molecular mode of action at the structural level still remains …
Role of Tat protein in HIV neuropathogenesis
W Li, G Li, J Steiner, A Nath - Neurotoxicity research, 2009 - Springer
The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …
pathophysiology of the neurocognitive deficits associated with HIV infection. This is the …
Didehydro-cortistatin A inhibits HIV-1 by specifically binding to the unstructured basic region of Tat
The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response
structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression …
structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression …
Clade‐specific differences in neurotoxicity of human immunodeficiency virus‐1 B and C Tat of human neurons: significance of dicysteine C30C31 motif
M Mishra, S Vetrivel, NB Siddappa… - Annals of …, 2008 - Wiley Online Library
Objective Human immunodeficiency virus‐1 (HIV‐1) causes mild to severe cognitive
impairment and dementia. The transactivator viral protein, Tat, is implicated in neuronal …
impairment and dementia. The transactivator viral protein, Tat, is implicated in neuronal …
HIV-1 Tat is a natively unfolded protein: the solution conformation and dynamics of reduced HIV-1 Tat-(1–72) by NMR spectroscopy
S Shojania, JD O'Neil - Journal of Biological Chemistry, 2006 - ASBMB
Tat (transactivator of transcription) is a small RNA-binding protein that plays a central role in
the regulation of human immunodeficiency virus type 1 replication and in approaches to …
the regulation of human immunodeficiency virus type 1 replication and in approaches to …
HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review
PT Gotora, R van der Sluis, ME Williams - BMC Infectious Diseases, 2023 - Springer
HIV-1 remains a global health concern and to date, nearly 38 million people are living with
HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by …
HIV. The complexity of HIV-1 pathogenesis and its subsequent prevalence is influenced by …
The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
GR Campbell, E Pasquier, J Watkins… - Journal of Biological …, 2004 - ASBMB
Human immunodeficiency virus (HIV) infection and the progression to AIDS are
characterized by the depletion of CD4+ T-cells. HIV-1 infection leads to apoptosis of …
characterized by the depletion of CD4+ T-cells. HIV-1 infection leads to apoptosis of …
What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
GR Campbell, EP Loret - Retrovirology, 2009 - Springer
The human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription protein Tat
is an important factor in viral pathogenesis. In addition to its function as the key trans …
is an important factor in viral pathogenesis. In addition to its function as the key trans …
Characterizing the interactions of cell-membrane-disrupting peptides with lipid-functionalized single-walled carbon nanotubes
Lipid-functionalized single-walled carbon nanotubes (SWNTs) have garnered significant
interest for their potential use in a wide range of biomedical applications. In this work, we …
interest for their potential use in a wide range of biomedical applications. In this work, we …