Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

Glucocorticoid hormones (cortisol and corticosterone-CORT) are the effector hormones of
the hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system. CORT is a systemic …

The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with
conflicting results. An umbrella review of meta-analyses of non-genetic peripheral …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

It is debated as to whether major depressive disorder (MDD) and the burnout syndrome
represent different aspects of the same syndrome or whether they reflect separate entities. A …

Stress responses are controlled by the hypothalamus pituitary adrenal (HPA)-axis and
maladaptive stress responses are associated with the onset and maintenance of stress …

A recent randomised, double-blind, placebo controlled study conducted by our research
group, provided partial support for the efficacy of supplementation with a patented curcumin …

Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic
stress on developmental trajectories. Such experiences can become biologically …

Stress is a state of derailed homeostasis and a main environmental risk factor for psychiatric
diseases. Chronic or uncontrollable stress may lead to a dysregulation of the hypothalamic …