Polysaccharide degradation by the Bacteroidetes: mechanisms and nomenclature

LS McKee, SL La Rosa, B Westereng… - Environmental …, 2021 - Wiley Online Library
The Bacteroidetes phylum is renowned for its ability to degrade a wide range of complex
carbohydrates, a trait that has enabled its dominance in many diverse environments. The …

Molecular strategies underlying Porphyromonas gingivalis virulence

IL Silva, E Cascales - Journal of Molecular Biology, 2021 - Elsevier
The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the
keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues …

The type IX secretion system: advances in structure, function and organisation

DG Gorasia, PD Veith, EC Reynolds - Microorganisms, 2020 - mdpi.com
The type IX secretion system (T9SS) is specific to the Bacteroidetes phylum. Porphyromonas
gingivalis, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins …

Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility

R Hennell James, JC Deme, A Kjӕr, F Alcock… - Nature …, 2021 - nature.com
Three classes of ion-driven protein motors have been identified to date: ATP synthase, the
bacterial flagellar motor and a proton-driven motor that powers gliding motility and the type 9 …

A unique bacterial secretion machinery with multiple secretion centers

L Song, JD Perpich, C Wu, T Doan… - Proceedings of the …, 2022 - National Acad Sciences
The Porphyromonas gingivalis type IX secretion system (T9SS) promotes periodontal
disease by secreting gingipains and other virulence factors. By in situ cryoelectron …

The type IX secretion system and its role in bacterial function and pathogenesis

PD Veith, MD Glew, DG Gorasia… - Journal of Dental …, 2022 - journals.sagepub.com
Porphyromonas, Tannerella, and Prevotella species found in severe periodontitis use the
Type IX Secretion System (T9SS) to load their outer membrane surface with an array of …

Dynamic proton-dependent motors power type IX secretion and gliding motility in Flavobacterium

MS Vincent, C Comas Hervada, C Sebban-Kreuzer… - PLoS …, 2022 - journals.plos.org
Motile bacteria usually rely on external apparatus like flagella for swimming or pili for
twitching. By contrast, gliding bacteria do not rely on obvious surface appendages to move …

Design principles of the rotary type 9 secretion system

A Trivedi, J Gosai, D Nakane… - Frontiers in Microbiology, 2022 - frontiersin.org
The Fo ATP synthase, the bacterial flagellar motor, and the bacterial type 9 secretion system
(T9SS) are the three known proton motive force driven biological rotary motors. In this …

Characterization of the O-Glycoproteome of Porphyromonas gingivalis

PD Veith, M Shoji, NE Scott… - Microbiology Spectrum, 2022 - Am Soc Microbiol
Porphyromonas gingivalis is an important human pathogen and also a model organism for
the Bacteroidetes phylum. O-glycosylation has been reported in this phylum with findings …

Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system

D Mizgalska, T Goulas… - Proceedings of the …, 2021 - National Acad Sciences
Porphyromonas gingivalis is a keystone pathogen of the human dysbiotic oral microbiome
that causes severe periodontitis. It employs a type-IX secretion system (T9SS) to shuttle …