Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis
A Peña-Cearra, J Castelo, JL Lavín… - Gut …, 2023 - Taylor & Francis
Anti-TNF therapy can induce and maintain a remission status during intestinal bowel
disease. However, up to 30% of patients do not respond to this therapy by mechanisms that …
disease. However, up to 30% of patients do not respond to this therapy by mechanisms that …
[HTML][HTML] CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis
S Khan, D Raj, S Sahu, A Naseer, NC Singh, S Kumari… - JCI insight, 2023 - ncbi.nlm.nih.gov
Altered mitochondrial function without a well-defined cause has been documented in
patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we …
patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we …
Mitochondrial dysfunction: unraveling the elusive biology behind anti-TNF response during ulcerative colitis
D Kioroglou, A Peña-Cearra, AM Corraliza, I Seoane… - bioRxiv, 2024 - biorxiv.org
Background Recent studies hint at mitochondrial genes influencing UC patient response to
anti-TNF treatment. We evaluated this hypothesis by following a targeted strategy to identify …
anti-TNF treatment. We evaluated this hypothesis by following a targeted strategy to identify …