Catalytic conversion of carbohydrates to initial platform chemicals: chemistry and sustainability

LT Mika, E Cséfalvay, Á Németh - Chemical reviews, 2018 - ACS Publications
The replacement of fossil resources that currently provide more than 90% of our energy
needs and feedstocks of the chemical industry in combination with reduced emission of …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications

J Lian, S Mishra, H Zhao - Metabolic engineering, 2018 - Elsevier
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

Biocatalyst for the synthesis of natural flavouring compounds as food additives: Bridging the gap for a more sustainable industrial future

S Singh, PK Sharma, S Chaturvedi, P Kumar… - Food Chemistry, 2024 - Elsevier
Biocatalysis entails the use of purified enzymes in the manufacturing of flavouring chemicals
food industry as well as at the laboratory level. These biocatalysts can significantly …

Metabolic engineering of Saccharomyces cerevisiae for the production of top value chemicals from biorefinery carbohydrates

SL Baptista, CE Costa, JT Cunha, PO Soares… - Biotechnology …, 2021 - Elsevier
The implementation of biorefineries for a cost-effective and sustainable production of energy
and chemicals from renewable carbon sources plays a fundamental role in the transition to a …

EasyClone‐MarkerFree: A vector toolkit for marker‐less integration of genes into Saccharomyces cerevisiae via CRISPR‐Cas9

MM Jessop‐Fabre, T Jakočiūnas… - Biotechnology …, 2016 - Wiley Online Library
Saccharomyces cerevisiae is an established industrial host for production of recombinant
proteins, fuels and chemicals. To enable stable integration of multiple marker‐free …

Advanced strategies for production of natural products in yeast

R Chen, S Yang, L Zhang, YJ Zhou - Iscience, 2020 - cell.com
Natural products account for more than 50% of all small-molecule pharmaceutical agents
currently in clinical use. However, low availability often becomes problematic when a …

Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis

XR Jiang, X Yan, LP Yu, XY Liu, GQ Chen - Nature communications, 2021 - nature.com
Hydroxypropionic acid (3HP), an important three carbon (C3) chemical, is designated as
one of the top platform chemicals with an urgent need for improved industrial production …

[HTML][HTML] Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine

I Borodina, KR Kildegaard, NB Jensen, TH Blicher… - Metabolic …, 2015 - Elsevier
Microbial fermentation of renewable feedstocks into plastic monomers can decrease our
fossil dependence and reduce global CO 2 emissions. 3-Hydroxypropionic acid (3HP) is a …

Improving production of malonyl coenzyme A-derived metabolites by abolishing Snf1-dependent regulation of Acc1

S Shi, Y Chen, V Siewers, J Nielsen - MBio, 2014 - Am Soc Microbiol
Acetyl coenzyme A (acetyl-CoA) carboxylase (ACCase) plays a central role in carbon
metabolism and has been the site of action for the development of therapeutics or …