In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae
A van Hooij, A Geluk - Immunological Reviews, 2021 - Wiley Online Library
Mycobacterium leprae, the causative agent of leprosy, is still actively transmitted in endemic
areas reflected by the fairly stable number of new cases detected each year. Recognizing …
areas reflected by the fairly stable number of new cases detected each year. Recognizing …
Mycobacterium leprae: genes, pseudogenes and genetic diversity
Leprosy, which has afflicted human populations for millenia, results from infection with
Mycobacterium leprae, an unculturable pathogen with an exceptionally long generation …
Mycobacterium leprae, an unculturable pathogen with an exceptionally long generation …
Immunology of leprosy and diagnostic challenges
I Nath, C Saini, VL Valluri - Clinics in Dermatology, 2015 - Elsevier
Leprosy, caused by noncultivable Mycobacterium leprae (ML), has varied manifestations,
which are associated with the host immune responses. The dermal involvement is …
which are associated with the host immune responses. The dermal involvement is …
The Role of Mycobacterium leprae Phenolic Glycolipid I (PGL-I) in Serodiagnosis and in the Pathogenesis of Leprosy
JS Spencer, PJ Brennan - Leprosy review, 2011 - leprosyreview.org
PGL-I (phenolic glycolipid I) emerged in the early 1980s on the one hand as part of intensive
efforts to define the typing antigens of a host of Mycobacterium spp. and also from …
efforts to define the typing antigens of a host of Mycobacterium spp. and also from …
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy
Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced
by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore …
by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore …
Analysis of Antibody Responses to Mycobacterium leprae Phenolic Glycolipid I, Lipoarabinomannan, and Recombinant Proteins To Define Disease Subtype-Specific …
JS Spencer, HJ Kim, WH Wheat… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
ABSTRACT A simple serodiagnostic test based on the Mycobacterium leprae-specific
phenolic glycolipid I (PGL-I), for individuals with leprosy is nearly universally positive in …
phenolic glycolipid I (PGL-I), for individuals with leprosy is nearly universally positive in …
[HTML][HTML] Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development
LH Sampaio, MMA Stefani, RM Oliveira… - BMC infectious …, 2011 - Springer
Background Leprosy is a chronic infectious disease caused by Mycobacterium leprae that
can manifest a wide variety of immunological and clinical outcomes ranging from potent …
can manifest a wide variety of immunological and clinical outcomes ranging from potent …
Challenges and advances in serological and molecular tests to aid leprosy diagnosis
L Lopes-Luz, DP Saavedra… - Experimental …, 2023 - journals.sagepub.com
Leprosy is a neglected chronic infectious disease caused by obligate intracellular bacilli,
Mycobacterium leprae and Mycobacterium lepromatosis. Despite multidrug therapy (MDT) …
Mycobacterium leprae and Mycobacterium lepromatosis. Despite multidrug therapy (MDT) …
Sensitivity and specificity of multibacillary and paucibacillary leprosy laboratory tests: a systematic review and meta-analysis
RT Torres, MM Fachi, B Böger, BM Marson… - … and Infectious Disease, 2021 - Elsevier
This systematic review (number register: CRD42018112736) was performed to compare the
sensitivity and specificity of leprosy diagnostic methods. The search was conducted in 3 …
sensitivity and specificity of leprosy diagnostic methods. The search was conducted in 3 …
[HTML][HTML] The long term effect of current and new interventions on the new case detection of leprosy: a modeling study
EAJ Fischer, SJ de Vlas, JDF Habbema… - PLoS neglected …, 2011 - journals.plos.org
Background Although the number of newly detected leprosy cases has decreased globally,
a quarter of a million new cases are detected annually and eradication remains far away …
a quarter of a million new cases are detected annually and eradication remains far away …