Biological functions of hCG and hCG-related molecules

LA Cole - Reproductive Biology and Endocrinology, 2010 - Springer
Background hCG is a term referring to 4 independent molecules, each produced by
separate cells and each having completely separate functions. These are hCG produced by …

The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology

M Simoni, J Gromoll, E Nieschlag - Endocrine reviews, 1997 - academic.oup.com
III. Molecular Structure of the FSH Receptor A. Cloning of the FSH receptor B. Predicted
primary structure of the FSH receptor C. Molecular mass of the FSH receptor IV. The FSH …

Structures of full-length glycoprotein hormone receptor signalling complexes

J Duan, P Xu, X Cheng, C Mao, T Croll, X He, J Shi… - Nature, 2021 - nature.com
Luteinizing hormone and chorionic gonadotropin are glycoprotein hormones that are related
to follicle-stimulating hormone and thyroid-stimulating hormone,. Luteinizing hormone and …

Inference of macromolecular assemblies from crystalline state

E Krissinel, K Henrick - Journal of molecular biology, 2007 - Elsevier
We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …

Intrinsic disorder and protein function

AK Dunker, CJ Brown, JD Lawson, LM Iakoucheva… - Biochemistry, 2002 - ACS Publications
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …

2.0 Å crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region

DJ Leahy, I Aukhil, HP Erickson - Cell, 1996 - cell.com
We have determined the 2.0 Å crystal structure of a fragment of human fibronectin
encompassing the seventh through the RGD-containing tenth type III repeats (FN7–10). The …

[29] Preparation of selenomethionyl proteins for phase determination

S Doublié - Methods in enzymology, 1997 - Elsevier
Publisher Summary The use of selenomethionyl proteins for phase determination is growing
in popularity for isomorphous replacement or multiwavelength anomalous dispersion (MAD) …

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

F Dyda, AB Hickman, TM Jenkins, A Engelman… - Science, 1994 - science.org
HIV integrase is the enzyme responsible for inserting the viral DNA into the host
chromosome; it is essential for HIV replication. The crystal structure of the catalytically active …

Two hormones for one receptor: evolution, biochemistry, actions, and pathophysiology of LH and hCG

L Casarini, D Santi, G Brigante, M Simoni - Endocrine reviews, 2018 - academic.oup.com
LH and chorionic gonadotropin (CG) are glycoproteins fundamental to sexual development
and reproduction. Because they act on the same receptor (LHCGR), the general consensus …

Structure of human follicle-stimulating hormone in complex with its receptor

QR Fan, WA Hendrickson - Nature, 2005 - nature.com
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-
protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian …