Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …

Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional
states throughout organism development. Epigenetics modifications, such as DNA …

DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …

Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …

Background: Aberrant expression of circular RNA contributes to human diseases. Circular
RNAs regulate gene expression by sequestering specific microRNAs. In this study, we …

Previous urinary tract infections (UTIs) can predispose one to future infections; however, the
underlying mechanisms affecting recurrence are poorly understood. We previously found …